| Description | Banoxantrone (AQ4N), a hypoxia-selective cytotoxin prototype, undergoes reduction to AQ4, effectively inhibiting topoisomerase II. It selectively targets and eradicates hypoxic cells through an iNOS-dependent mechanism. This compound demonstrates significant cytotoxicity with its hypoxia-selective action being augmented by radiation. |
| Synonyms | AQ4N |
| molecular weight | 444.48 |
| Molecular formula | C22H28N4O6 |
| CAS | 136470-65-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |