| Description | BAN ORL 24 is a potent and selective NOP receptor antagonist (IC50s: 0.27, 2500, 6700 and > 10000 nM for NOP, κ-, μ- and δ-receptors). |
| In vitro | BAN ORL 24 inhibits nociceptin-induced stimulation of [35S]-GTPγS binding and Ca2+ mobilization in CHO cells in vitro. |
| In vivo | BAN ORL 24 antagonizes NOP agonist-induced reduction in locomotor activity in vivo. |
| molecular weight | 506.51 |
| Molecular formula | C27H37Cl2N3O2 |
| CAS | 1401463-54-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | H2O: 50 mg/mL (98.71 mM) |
| References | 1. Fischetti et al (2009) Pharmacological characterization of the nociceptin/orphanin FQ receptor non peptide antagonist compound 24. Eur.J.Pharmacol. 614 50. |