| Description | BACE1-IN-13 (Compound 36), an orally active inhibitor of BACE1, exhibits high potency with an IC50 of 2.9 nM and demonstrates greater efficacy in hAβ42 cells (IC50 = 1.3 nM). It is considered safe for the cardiovascular system and induces a sustained reduction of Aβ42 in both mouse and dog animal models [1]. |
| molecular weight | 420.4 |
| Molecular formula | C20H17FN8O2 |
| CAS | 1397683-26-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |