| Description | B355252 protects against cell death caused by glutamate-evoked oxidative stress. B355252 shows neuroprotective effect, potentiating nerve growth factor (NGF)-induced neurite outgrowth. |
| In vitro | 方法：HT22细胞预处理2小时，使用不同浓度的B355252（0.625-20 μM），随后加入300 μM CoCl2，并在37℃孵育24小时。此后，通过resazurin试验确定细胞活力，具体方法如下所述。结果：在0.625至5 μM范围内，B355252以剂量依赖的方式提高了细胞活力，保护细胞免受CoCl2引起的低氧伤害。超过5 μM时，B355252对细胞产生毒性，并与CoCl2协同作用，降低了细胞活力。 |
| molecular weight | 514.06 |
| Molecular formula | C25H24ClN3O3S2 |
| CAS | 1261576-81-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 25 mg/mL (48.63 mM) |
| References | 1. Chimeh U , Zimmerman M A , Gilyazova N , et al. B355252, A Novel Small Molecule, Confers Neuroprotection Against Cobalt Chloride Toxicity In Mouse Hippocampal Cells Through Altering Mitochondrial Dynamics And Limiting Autophagy Induction[J]. International Journal of Medical Sciences, 2018, 15(12):1384-1396. |