| Description | Azimilide Dihydrochloride (NE-10064 Dihydrochloride), a novel class III antiarrhythmic agent, blocks both the slowly activating (IKs) and rapidly activating (IKr) components of the delayed rectifier potassium current |
| In vivo | Azimilide has shown excellent efficacy (>85%) in suppressing supraventricular arrhythmias in a variety of dog models.?It also suppressed complex ventricular arrhythmias in infarcted dogs and, in a sudden death cardiac model, decreased mortality[1]. |
| Synonyms | NE-10064 Dihydrochloride, 盐酸阿齐利特 |
| molecular weight | 530.88 |
| Molecular formula | C23H30Cl3N5O3 |
| CAS | 149888-94-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 8.46 mg/mL (15.94 mM) |
| References | 1. Karam R , Marcello S , Brooks R R , et al. Azimilide Dihydrochloride, a Novel Antiarrhythmic Agent[J]. American Journal of Cardiology, 1998, 81(6-supp-S1):40-46. 2. Abrol R , Page R L . Azimilide dihydrochloride: a new class III anti-arrhythmic agent[J]. Expert Opinion on Investigational Drugs, 2000, 9(11):2705-2715. |