| Description | AZD3988 is an orally active and highly potent inhibitor of diacylglycerol acyltransferase-1 (DGAT-1) for the study of diabetes and obesity. |
| In vitro | 在小鼠、大鼠和狗中，AZD3988（0.5、1、2、5 mg/kg；静脉注射）表现出良好的生物利用度[1]。 |
| Target activity | DGAT-1 (rat):5 nM, DGAT-1 (mouse):11 nM, DGAT-1 (human):6 nM, DGAT-1 (human):6 nM |
| molecular weight | 456.44 |
| Molecular formula | C23H22F2N4O4 |
| CAS | 892489-52-0 |
| Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 10 mg/mL (21.91 mM), Sonification is recommended. |
| References | 1. McCoull W, et al. Identification, optimisation and in vivo evaluation of oxadiazole DGAT-1 inhibitors for the treatment of obesity and diabetes. Bioorg Med Chem Lett. 2012 Jun 15;22(12):3873-8. |