| Description | AZD1979 is an antagonist of Melanin-concentrating hormone receptor 1 (MCHr1) (IC50: 12 nM). |
| In vivo | In DIO mice, initial AZD1979-mediate body weight loss is driven by decreasing food intake. However, an additional component of preserving energy expenditure is apparent in pair-feeding and indirect calorimetry studies. AZD1979 also dose-dependently reduces body weight in dogs[1]. |
| Target activity | MCHR1:~12 nM |
| molecular weight | 462.5 |
| Molecular formula | C25H26N4O5 |
| CAS | 1254035-84-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Ploj K, et al. Effects of a novel potent melanin-concentrating hormone receptor 1 antagonist, AZD1979, on body weight homeostasis in mice and dogs. Br J Pharmacol. 2016 Sep;173(18):2739-51. |