| Description | AZD2461 is a novel PARP inhibitor. |
| In vitro | AZD2461在抗Olaparib的KB1P肿瘤T6-28上Mdr1b表达增加了80倍,没有抑制Pgp. |
| In vivo | AZD2461比奥拉帕尼对Pgp的亲和力低。 |
| Target activity | PARP3:200 nM, PARP2:2 nM, PARP1:5 nM |
| molecular weight | 395.43 |
| Molecular formula | C22H22FN3O3 |
| CAS | 1174043-16-3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 45 mg/mL (113.8 mM) Ethanol: 39.5 mg/mL (100 mM) |
| References | 1. Jaspers JE, et al. Cancer Discov, 2013, 3(1), 68-81. |
| Citations | 1. Zhao J, Xu J, Wu M, et al.LncRNA H19 Regulates Breast Cancer DNA Damage Response and Sensitivity to PARP Inhibitors via Binding to ILF2.International Journal of Molecular Sciences.2023, 24(11): 9157. |