| Description | AZD-1897 is an ATP-competitive pan-PIM inhibitor. When combined with the Akt inhibitor AZD5363, AML cells from putative leukaemia stem cells incur a reduction in levels of the anti-apoptotic protein MCL1. The combination of PIM and Akt inhibition holds promise for the treatment of AML. |
| molecular weight | 361.46 |
| Molecular formula | C18H23N3O3S |
| CAS | 1204181-93-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |