| Description | AZ12971554 is a potent inhibitor of human thrombin. Ki = 0.3nM, Activated partial thromboplastin time (APTT) IC50 = 0.68µM, Ecarin clotting time (ECT) IC50 = 0.16µM in human plasma. |
| Synonyms | AZ 12971554, AZ-12971554 |
| molecular weight | 457.85 |
| Molecular formula | C20H17ClFN7O3 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Karlsson S, Branalt J, Halvarsson MO, Bergman J. (2014) A One-Pot Asymmetric Synthesis of a N Acylated 4,5- Dihydropyrazole, A Key Intermediate of Thrombin Inhibitor AZD8165. Organic Process Research and Development, 18: 969-975. |