| Description | AZ12441970 is an effective agonist of Toll-like receptor 7 (TLR7 agonist). |
| Synonyms | AZ-12441970, AZ 12441970 |
| molecular weight | 527.66 |
| Molecular formula | C27H41N7O4 |
| CAS | 929551-91-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Edwards S, Jones C, Leishman AJ, Young BW, Matsui H, Tomizawa H, Murray CM, Biffen M. TLR7 stimulation of APCs results in inhibition of IL-5 through type I IFN and Notch signaling pathways in human peripheral blood mononuclear cells. J Immunol. 2013 Mar 15;190(6):2585-92. doi: 10.4049/jimmunol.1200780. Epub 2013 Feb 4. PubMed PMID: 23382558. 2. Biffen M, Matsui H, Edwards S, Leishman AJ, Eiho K, Holness E, Satterthwaite G, Doyle I, Wada H, Fraser NJ, Hawkins SL, Aoki M, Tomizawa H, Benjamin AD, Takaku H, McInally T, Murray CM. Biological characterization of a novel class of toll-like receptor 7 agonists designed to have reduced systemic activity. Br J Pharmacol. 2012 May;166(2):573-86. doi: 10.1111/j.1476-5381.2011.01790.x. PubMed PMID: 22122192; PubMed Central PMCID: PMC3417490. |