| Description | AZ084 is a potent, selective, allosteric, and oral active CCR8 antagonist (Ki: 0.9 nM). It has the potential to treat asthma. |
| Target activity | CCR8:0.9 nM (ki) |
| molecular weight | 434.57 |
| Molecular formula | C26H34N4O2 |
| CAS | 929300-19-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 240 mg/mL (552.27 mM), Sonication is recommended. |
| References | 1. Connolly S, et al. Orally bioavailable allosteric CCR8 antagonists inhibit dendritic cell, T cell and eosinophil migration. Biochem Pharmacol. 2012 Mar 15;83(6):778-87. |