| Description | AVE5688 is an inhibitor of glycogen phosphorylase (GP, IC50s: 430 nM and 915 nM; Kds: 170 nM and 530 nM for rmGPb and rmGPa). It can be used for the research of type 2 diabetes. |
| Target activity | GPa (rabbit muscle):530 nM , GPa (rabbit muscle):915 nM , GPb (rabbit muscle):(kd)170 nM , GPb (rabbit muscle):430 nM |
| molecular weight | 438.69 |
| Molecular formula | C16H8ClF5N2O5 |
| CAS | 613260-13-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 55 mg/mL (125.37 mM) |
| References | 1. Anderka O, et al. Thermodynamic characterization of allosteric glycogen phosphorylase inhibitors. Biochemistry. 2008 Apr 22;47(16):4683-91. |