| Description | AVE1231 is a TASK-1 channel blocker that inhibits TASK-1 and can be used in the study of atrial fibrillation. |
| molecular weight | 405.51 |
| Molecular formula | C20H27N3O4S |
| CAS | 767334-89-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Shvetsova AA,et al. TASK-1 channel blockade by AVE1231 increases vasocontractile responses and BP in 1- to 2-week-old but not adult rats. Br J Pharmacol. 2020 Nov;177(22):5148-5162. 2. Wiedmann F, et al. Identification of the A293 (AVE1231) Binding Site in the Cardiac Two-Pore-Domain Potassium Channel TASK-1: a Common Low Affinity Antiarrhythmic Drug Binding Site. Cell Physiol Biochem. 2019;52(5):1223-1235. |