| Description | AV-153 free base is a 1,4-dihydropyridine (1,4-DHP) derivative. AV-153 free base is an antimutagenic with anti-cancer activity. AV-153 free base interacts with cytosine and thymine and has an influence on poly(ADP)ribosylation. AV-153 free base intercalates to DNA in a single strand break and reduces DNA damage, stimulates DNA repair in human cells in vitro [1] [2] [3]. |
| In vitro | AV-153 free base causes IC 50 s for Raji and HL-60 cells of 14.9 mM and 10.3 mM, respectively [1]. AV-153 free base (1 nM to 10 μM; 3 hours) reduces the level of spontaneously arising DNA single-strand breaks (SSBs) in peripheral blood lymphocytes or HL-60 cells by 13–67% [1]. |
| molecular weight | 297.3 |
| Molecular formula | C14H19NO6 |
| CAS | 19350-66-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |