| Description | Auxinole, a potent antagonist of TIR1/AFB auxin receptors, effectively binds to TIR1, inhibiting the formation of the TIR1-IAA-Aux/IAA complex. This action blocks auxin-responsive gene expression. |
| In vitro | Auxinole 是一种强效的 TIR1/AFB 受体的生长素拮抗剂。它还能结合 TIR1，阻断 TIR1-IAA-Aux/IAA 复合体的形成，进而抑制生长素反应基因的表达。Auxinole 降低了 IAA 触发的根毛细胞去极化现象。此外，Auxinole 在植物体内以竞争性方式抑制各种生长素反应[1]。Auxinole (20 μM) 也完全抑制了 [Ca2+]cyt 瞬时增加，并阻断了 Ca2+ 响应[2]。 |
| molecular weight | 321.37 |
| Molecular formula | C20H19NO3 |
| CAS | 86445-22-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | Ethanol: 12.5 mg/mL (38.90 mM), Sonication is recommended. DMSO: 125 mg/mL (388.96 mM) |
| References | 1. Hayashi K, et al. Rational design of an auxin antagonist of the SCF(TIR1) auxin receptor complex. ACS Chem Biol. 2012 Mar 16;7(3):590-8. 2. Dindas J, et al. AUX1-mediated root hair auxin influx governs SCFTIR1/AFB-type Ca2+ signaling. Nat Commun. 2018 Mar 21;9(1):1174. |