| Description | ATP synthase inhibitor 1 is an inhibitor of the c subunit of the F1/FO-ATP synthase complex. It inhibits mitochondrial permeability transition pore (mPTP) opening and does not affect ATP levels. |
| In vitro | ATP synthase inhibitor 1 is a potent inhibitor of c subunit of the F1/FO-ATP synthase complex[1]. |
| molecular weight | 411.93 |
| Molecular formula | C17H18ClN3O3S2 |
| CAS | 1023043-30-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.94 mg/mL (12 mM) |
| References | 1. Morciano G, et al. Discovery of Novel 1,3,8-Triazaspiro[4.5]decane Derivatives That Target the c Subunit of F1/FO-Adenosine Triphosphate (ATP) Synthase for the Treatment of Reperfusion Damage in Myocardial Infarction. J Med Chem. 2018 Aug 23;61(16):7131-7143. |