| Description | ATL-801 is anselective antagonist of A2B receptor with herapeutic activity for colitis. |
| molecular weight | 459.5 |
| Molecular formula | C24H25N7O3 |
| CAS | 1000005-71-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kolachala V, Ruble B, Vijay-Kumar M, Wang L, Mwangi S, Figler H, Figler R, Srinivasan S, Gewirtz A, Linden J, Merlin D, Sitaraman S. Blockade of adenosine A2B receptors ameliorates murine colitis. Br J Pharmacol. 2008 Sep;155(1):127-37. doi: 10.1038/bjp.2008.227. Epub 2008 Jun 9. PubMed PMID: 18536750; PubMed Central PMCID: PMC2440087. 2. Tian Y, Piras BA, Kron IL, French BA, Yang Z. Adenosine 2B Receptor Activation Reduces Myocardial Reperfusion Injury by Promoting Anti-Inflammatory Macrophages Differentiation via PI3K/Akt Pathway. Oxid Med Cell Longev. 2015;2015:585297. doi: 10.1155/2015/585297. Epub 2015 Jun 16. PubMed PMID: 26161239; PubMed Central PMCID: PMC4486757. 3. Maas JE, Wan TC, Figler RA, Gross GJ, Auchampach JA. Evidence that the acute phase of ischemic preconditioning does not require signaling by the A 2B adenosine receptor. J Mol Cell Cardiol. 2010 Nov;49(5):886-93. doi: 10.1016/j.yjmcc.2010.08.015. Epub 2010 Aug 24. PubMed PMID: 20797398; PubMed Central PMCID: PMC2958103. |