| Description | ATB107 hydrochloride is a novel and potent inhibitor of indole-3-glycerol phosphate synthase (IGPS) with a KD of 3 μM. |
| In vitro | ATB107 hydrochloride 对M. tuberculosis H37Ra的最小抑菌浓度（MIC）为0.1 μg/mL。ATB107 hydrochloride 对M. tuberculosis H37Rv也显示出高活性，MIC为0.1 μg/mL。在测试的50个完全敏感的临床分离株中，所有分离株对1 μg/mL浓度的ATB107 hydrochloride敏感；其中41株（82%）对0.1 μg/mL的ATB107 hydrochloride敏感。研究结果还显示，67株（83.8%）多药耐药性结核病（MDR-TB）分离株对1 μg/mL浓度的ATB107 hydrochloride敏感，25株（31.3%）分离株对0.1 μg/mL浓度的ATB107 hydrochloride敏感。结果表明，ATB107 hydrochloride的结合能力与其浓度相关。在高浓度200 μg/mL下，ATB107 hydrochloride能抑制细胞增殖，存活率约为60%。在较低的50 μg/mL浓度下，ATB107 hydrochloride的细胞存活率超过80%[1]。 |
| Synonyms | ATB107 hydrochloride(455325-51-6 Free base) |
| molecular weight | 428.96 |
| Molecular formula | C21H29ClN8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 4.29 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Shen H, et al. A novel inhibitor of indole-3-glycerol phosphate synthase with activity against multidrug-resistant Mycobacterium tuberculosis. FEBS J. 2009 Jan;276(1):144-54. |