| Description | ASP-4000 HCl is an inhibitor of dipeptidyl peptidase 4 (DPP) with anti-hyperglycemic activity. |
| Synonyms | ASP4000 HCl, ASP 4000 HCl, UNII-7393JFE67B |
| molecular weight | 271.74 |
| Molecular formula | C12H18ClN3O2 |
| CAS | 851389-35-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Tanaka-Amino K, Hatakeyama Y, Takakura S, Mutoh S. Constitutive increase in active GLP-1 levels by the DPP4 inhibitor ASP4000 on a new meal tolerance test in Zucker fatty rats. Pharmacol Res. 2009 Oct;60(4):264-9. doi: 10.1016/j.phrs.2009.03.018. Epub 2009 Apr 7. PubMed PMID: 19520592. 2. Tanaka-Amino K, Matsumoto K, Hatakeyama Y, Takakura S, Mutoh S. ASP4000, a slow-binding dipeptidyl peptidase 4 inhibitor, has antihyperglycemic activity of long duration in Zucker fatty rats. Acta Diabetol. 2010 Mar;47(1):43-8. doi: 10.1007/s00592-009-0096-5. Epub 2009 Feb 24. PubMed PMID: 19238312. 3. Tanaka-Amino K, Matsumoto K, Hatakeyama Y, Shima I, Takakura S, Muto S. ASP4,000, a novel, selective, dipeptidyl peptidase 4 inhibitor with antihyperglycemic activity. Eur J Pharmacol. 2008 Aug 20;590(1-3):444-9. doi: 10.1016/j.ejphar.2008.05.034. Epub 2008 Jun 24. PubMed PMID: 18582861. |