| Description | ART-CHEM-BB B025267 is the upregulator of utrophin production with EC50 of 1.8 μM and can be used in research on the treatment of Duchenne muscular dystrophy. |
| Target activity | Utrophin:1.8 μM (EC50) |
| Synonyms | 2-(4-二乙基氨基苯基)-6-甲基-5-苯并三唑胺 |
| molecular weight | 295.38 |
| Molecular formula | C17H21N5 |
| CAS | 381208-40-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/mL (186.2 mM) |
| References | 1. De Moor O, et al. Discovery and SAR of 2-arylbenzotriazoles and 2-arylindazoles as potential treatments for Duchenne muscular dystrophy. Bioorg Med Chem Lett. 2011 Aug 15;21(16):4828-31. 2. Chancellor DR, et al. Discovery of 2-arylbenzoxazoles as upregulators of utrophin production for the treatment of Duchenne muscular dystrophy. J Med Chem. 2011 May 12;54(9):3241-50. |