| Description | ARN14974 is a benzoxazolone carboxamide. ARN14974 is a potent inhibitor of acid ceramidase with IC50 of 79 nM[1]. |
| molecular weight | 404.43 |
| Molecular formula | C24H21FN2O3 |
| CAS | 1644158-57-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 15 mg/ml (37.09 mM) |
| References | 1. Bach A, Pizzirani D, Realini N, Vozella V, Russo D, Penna I, Melzig L, Scarpelli R, Piomelli D. Benzoxazolone Carboxamides as Potent Acid Ceramidase Inhibitors: Synthesis and Structure-Activity Relationship (SAR) Studies. J Med Chem. 2015 Dec 10;58(23):9258-72. doi: 10.1021/acs.jmedchem.5b01188. Epub 2015 Nov 23. |