| Description | ARN1468 (compound 5) is a highly effective orally active inhibitor of serpins. Inhibition of serpins activity by ARN1468 enables release of proteases, thereby reducing prion accumulation. ARN1468 demonstrates pronounced anti-prion effects in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC 50 values of 8.64, 19.3, 11.2, and 6.27 μM [1]. |
| In vivo | ARN1468 (compound 5) (3 mg/kg, IV; 10 mg/kg, PO; once) reveals low brain concentrations and high plasma clearance in male C57BL/6 mice [1]. |
| molecular weight | 354.33 |
| Molecular formula | C16H17F3N4O2 |
| CAS | 1381459-14-8 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |