| Description | Argireline (Acetyl hexapeptide-3) is composed of chains of amino acids known as peptides. Argireline significantly inhibits Ca2+ dependent neurotransmitter release (acetylcholine) at the neuromuscular junction. Argireline has antiwrinkle and anti-aging activity[1][2][3]. |
| In vitro | Argireline溶液在不同浓度下与人胚肾HEK-293细胞（IC50为34.862 μM）和神经母细胞瘤IMR-32细胞（IC50为68.458 μM）共孵育48小时，显示出剂量依赖性的抗增殖效应。不同浓度的Argireline溶液与HSF共孵育对这些细胞也表现出剂量依赖性的抗增殖效果。低浓度的Argireline不影响细胞增殖[2]。 |
| In vivo | Argireline两次日应用于老年小鼠，持续6周。结果显示，老年小鼠的皮肤组织的组织结构有所改善；I型胶原纤维的含量增加(P < 0.01)，而III型胶原纤维的含量减少(P < 0.05)。Argireline能够改善皮肤组织的组织结构，使老化皮肤恢复年轻[3]。 |
| Synonyms | 六胜肽, Acetyl hexapeptide-3, 阿基瑞林 |
| molecular weight | 888.99 |
| Molecular formula | C34H60N14O12S |
| CAS | 616204-22-9 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 10 mM |
| References | 1. Blanes-Mira C, et al. A synthetic hexapeptide (Argireline) with antiwrinkle activity. Int J Cosmet Sci. 2002 Oct;24(5):303-10. |