| Description | Argifin is a sub-nanomolar chitinase inhibitor produced by soil microorganisms (IC50: 0.025 μM, 6.4 μM, 1.1 μM and 4.5 μM for SmChiA (Serratia marcescens chitinaese A), SmChiB, Aspergillus fumigatus chitinase B1 and human chitotriosidase). |
| In vitro | Argifin inhibits L. cuprina chitinase (IC50s: 3.7 μM at 37 oC and 0.10 μM at 20 oC) |
| Target activity | SmChiB:6.4 μM , Chitotriosidase (human):4.5 μM , Chitinase B1 (aspergillus fumigatus):1.1 μM , SmChiA:0.025 μM |
| molecular weight | 675.7 |
| Molecular formula | C29H41N9O10 |
| CAS | 243975-37-3 |
| Storage | keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Hirose T, et al. Recent development of two chitinase inhibitors, Argifin and Argadin, produced by soil microorganisms. Proc Jpn Acad Ser B Phys Biol Sci. 2010;86(2):85-102. |