(Arg)9 TFA (143413-47-2 free base) Bioactivity,Chemical Properties,Storage & Solubility Information Pathways-PeptideDB

Description	(Arg)9 TFA (Peptide R9 TFA) is a cell-penetrating peptide. (Arg)9 TFA (Nona-L-arginine TFA) exhibits neuroprotective activity with an IC50 of 0.78 μM in the glutamic acid model.
In vivo	(Arg)9 (D-isoform) 在大鼠中风模型中显示出神经保护作用。该化合物具有显著的神经保护能力，其有效性随着精氨酸含量的增加而提高。它能够减少谷氨酸诱导的神经元钙内流，并需要通过肝素硫酸蛋白聚糖介导的内吞作用来产生神经保护效果[2]。(Arg)9 (D-isoform) 在永久性中脑动脉闭塞(MCAO)后30分钟以1000 nmol/kg的剂量静脉注射，可以减少梗死体积[3]。
Target activity	Neuroprotection:0.78 μM (IC50)
Synonyms	Nona-L-arginine (TFA), (Arg)9 TFA, Peptide R9 (TFA)
molecular weight	1537.71
Molecular formula	C56H111F3N36O12
CAS	2283335-13-5
Storage	keep away from moisture \| Powder: -20°C for 3 years \| In solvent: -80°C for 1 year \| Shipping with blue ice.
Solubility	H2O: 10 mM DMSO: Insoluble
References	1. Meloni BP, et al. The neuroprotective efficacy of cell-penetrating peptides TAT, penetratin, Arg-9, and Pep-1 in glutamic acid, kainic acid, and in vitro ischemia injury models using primary cortical neuronal cultures. Cell Mol Neurobiol. 2014 Mar;34(2):173-81.

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