| Description | Arbidol (Umifenovir) is an orally active broad-spectrum antiviral compound that is a fusion inhibitor and interacts with the SARS-CoV-2 spicule protein.Arbidol shows inhibitory activity against a variety of coronaviruses.Arbidol has anti-inflammatory and antioxidant activity and may be useful for the study of concentrated infections. |
| In vitro | Arbidol 对多种病毒具有强大的抗病毒活性，包括流感病毒 A、B 和 C、呼吸道合胞病毒、SARS-CoV、腺病毒、副流感病毒 5 型、脊髓灰质炎病毒 1、鼻病毒 14、柯萨奇病毒 B5、汉坦病毒、基孔肯雅病毒、HBV 和 HCV。[1] |
| In vivo | Arbidol（25 和 45 mg/ml；口服；6-8 周龄 BALB/c 小鼠）对感染流感病毒的小鼠表现出存活益处。与病毒组相比，Arbidol 提高了小鼠的存活率，在 45 mg/mL 剂量下抑制了小鼠体重下降，在 25 mg/mL 和 45 mg/mL 剂量下抑制了小鼠肺指数的增加。[3] |
| Synonyms | Umifenovir |
| molecular weight | 477.42 |
| Molecular formula | C22H25BrN2O3S |
| CAS | 131707-25-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Blaising J, et al. Arbidol as a broad-spectrum antiviral: an update. Antiviral Res. 2014 Jul;107:84-94. 2. Leneva I, et al. Antiviral Activity of Umifenovir In Vitro against a Broad Spectrum of Coronaviruses, Including the Novel SARS-CoV-2 Virus. Viruses. 2021 Aug 23;13(8):1665. 3. Wang Y, et al. Inhibition of the infectivity and inflammatory response of influenza virus by Arbidol hydrochloride in vitro and in vivo (mice and ferret). Biomed Pharmacother. 2017 Jul;91:393-401. |