| Description | APX001 is a prodrug of APX-001A. APX001 is the first-in-class inhibitor of the fungal protein Gwt1. |
| Synonyms | APX 001, APX-001 |
| molecular weight | 468.4 |
| Molecular formula | C22H21N4O6P |
| CAS | 1169701-00-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Zhao M, Lepak AJ, VanScoy B, Bader JC, Marchillo K, Vanhecker J, Ambrose PG, Andes DR. In Vivo Pharmacokinetics and Pharmacodynamics of APX001 against Candida spp. in a Neutropenic Disseminated Candidiasis Mouse Model. Antimicrob Agents Chemother. 2018 Jan 29. pii: AAC.02542-17. doi: 10.1128/AAC.02542-17. [Epub ahead of print] PubMed PMID: 29378706. 2. Hager CL, Larkin EL, Long L, Zohra Abidi F, Shaw KJ, Ghannoum MA. In Vitro and In Vivo Evaluation of the Antifungal Activity of APX001A/APX001 against Candida auris. Antimicrob Agents Chemother. 2018 Feb 23;62(3). pii: e02319-17. doi: 10.1128/AAC.02319-17. Print 2018 Mar. PubMed PMID: 29311065. 3. Gonzalez-Lara MF, Sifuentes-Osornio J, Ostrosky-Zeichner L. Drugs in Clinical Development for Fungal Infections. Drugs. 2017 Sep;77(14):1505-1518. doi: 10.1007/s40265-017-0805-2. PubMed PMID: 28840541. 4. Osherov N, Kontoyiannis DP. The anti-Aspergillus drug pipeline: Is the glass half full or empty? Med Mycol. 2017 Jan 1;55(1):118-124. Epub 2016 Aug 25. Review. PubMed PMID: 27562862. |