| Description | Aprocitentan D4 (ACT-132577 D4) is a deuterium-labeled Aprocitentan. Aprocitentan is a major and pharmacologically active metabolite of Macitentan. Aprocitentan is a dual ETA/ETB antagonist (IC50s: 3.4 nM and 987 nM; pA2s: 6.7 and 5.5). |
| Target activity | ETB:5.5, ETB:987 nM, ETA:3.4 nM, ETA:6.7(pA2) |
| Synonyms | ACT-132577 D4 |
| molecular weight | 550.22 |
| Molecular formula | C16H10D4Br2N6O4S |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Iglarz M, et al. Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. J Pharmacol Exp Ther. 2008 Dec;327(3):736-45. |