| Description | Apigenin-7-glucuronide (Apigenin 7-O-glucuronide) possesses multiple activities, including antioxidant, anti-inflammatory, and aldose reductase inhibitory activities, it can inhibit MMP activities (IC50s: 12.87, 22.39, 17.52, 0.27 μM for MMP-3, MMP-8, MMP-9, MMP-13, respectively). |
| In vivo | Apigenin-7-glucuronide（AG）在剂量依赖性的方式下，抑制了脂多糖（LPS）刺激的RAW 264.7巨噬细胞中一氧化氮（NO）、前列腺素E2（PGE2）及肿瘤坏死因子-α（TNF-α）的释放，同时不影响细胞活力。此外，AG抑制了LPS诱导的诱导型一氧化氮合酶（iNOS）、环氧化酶-2（COX-2）和TNF-α的mRNA表达。AG处理减少了c-Jun进入核内的转移，并通过抑制p38丝裂原活化蛋白激酶（MAPK）和细胞外信号调节激酶（ERK）的磷酸化，降低了激活蛋白-1（AP-1）介导的荧光素酶活性[2]。 |
| Target activity | MMP13:0.27 μM, MMP9:17.52 μM, MMP8:22.39 μM, MMP3:12.87 μM |
| Synonyms | Apigenin 7-O-glucuronide, 芹菜素-7-葡萄糖醛酸 |
| molecular weight | 446.36 |
| Molecular formula | C21H18O11 |
| CAS | 29741-09-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (112.02 mM) |
| References | 1. Crascì L, et al. Correlating In Vitro Target-Oriented Screening and Docking: Inhibition of Matrix Metalloproteinases Activities by Flavonoids. Planta Med. 2017 Jul;83(11):901-911. 2. Hu W, et al. Apigenin-7-O-β-D-glucuronide inhibits LPS-induced inflammation through the inactivation of AP-1 and MAPK signaling pathways in RAW 264.7 macrophages and protects mice against endotoxin shock. Food Funct. 2016 Feb;7(2):1002-13. |