| Description | APC 366 (TFA) is a potent irreversible inhibitor of mast cell tryptase. It is particularly useful in studies related to allergic diseases. |
| In vivo | APC 366 (TFA) (5 mg/kg/0.1 ml; s.c.) reduces the eosinophil recruitment induced by PAR-2 activating peptide[1]. Animal Model: Male BALB/c mice (18–25 g)[1]Dosage: 5 mg/kg/0.1 ml Administration: S.c. Result: Reduced the eosinophil recruitment induced by PAR-2 activating peptide. |
| molecular weight | 554.527 |
| Molecular formula | C24H29F3N6O6 |
| CAS | 2421110-28-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Matos NA, et al. Mast cell tryptase induces eosinophil recruitment in the pleural cavity of mice via proteinase-activated receptor 2. Inflammation. 2013;36(6):1260-1267. |