| Description | AP1189 acetate is a biased agonist at melanocortin 1 and melanocortin 3 receptors. |
| In vitro | 向巨噬细胞培养物中加入AP1189，可降低细胞因子的释放量，这一效果依赖于MC1和MC3的共同作用，通过使用Mc1r(-/-)和Mc3r(-/-)巨噬细胞得以明显证实。在B16-F10黑色素瘤细胞中，AP1189未引起黑色素生成[1]。 |
| In vivo | 口服AP1189在腹膜炎中引发抗炎作用，且在炎症高峰期给药可将解决炎症的阶段加速约3倍[1]。 |
| molecular weight | 358.35 |
| Molecular formula | C16H18N6O4 |
| CAS | 959850-74-9 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 50 mg/mL (139.53 mM) |
| References | 1. Montero-Melendez T, et al. Biased agonism as a novel strategy to harness the proresolving properties of melanocortin receptors without eliciting melanogenic effects. J Immunol. 2015 Apr 1;194(7):3381-8. |