| Description | Antitumor agent-87 is an antitumor agent with antiproliferative activity that induces cell cycle arrest. |
| In vitro | 在 MCF7、HT-29 和 M21 细胞中，Antitumor agent-87 ( 0-12500 nM;48小时)表现出抗增殖活性，IC50 值分别为 600 nM、>12500 nM和 >12500 nM[1]。 |
| In vivo | Antitumor agent-87 (0.1 µg/egg) 在移植的 HT-1080 雏鸡胚胎中表现出 29% 的抗肿瘤活性[1]。 |
| Target activity | M21:>12500 nM, MCF7:600 nM, CYP1A1:0.23 μM (Ki), MLKL (HT-29 cells):>12500 nM |
| molecular weight | 448.53 |
| Molecular formula | C22H28N2O6S |
| CAS | 1422527-88-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| References | 1. Chavez Alvarez AC, et al. Homologation of the Alkyl Side Chain of Antimitotic Phenyl 4-(2-Oxo-3-alkylimidazolidin-1-yl)benzenesulfonate Prodrugs Selectively Targeting CYP1A1-Expressing Breast Cancers Improves Their Stability in Rodent Liver Microsomes. J Med Chem. 2023 Feb 23;66(4):2477-2497. |