| Description | Antitumor agent-28 is a compound that specifically targets and inhibits the activity of the ataxia telangiectasia mutated (ATM) kinase. By doing so, it effectively impedes the progression of ATM-mediated diseases and demonstrates significant anti-cancer activity. |
| In vitro | Antitumor agent-28 inhibits ataxia telangiectasia mutated (ATM; IC 50 =7.6 nM; HT29 cells), ataxia telangiectasia and Rad3-related protein (ATR; IC 50 =18 μM; HT29 cells), PI3Ka (IC 50 =0.24 μM; BT474 cells). Antitumor agent-28 does not inhibit mTOR in MDA-MB-468 cells[1]. |
| molecular weight | 512.63 |
| Molecular formula | C25H32N6O4S |
| CAS | 2097499-67-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kurt Gordon Pike, et al. Composés imidazo[4,5c]quinoline-2-one et leur utilisation dans le traitement du cancer. WO2017076898A1. |