| Description | Antitumor agent-19 is a modulator of tumor-associated macrophages with EC50s of 17.18 μM and 18.87 μM in the RAW 264.7 cells and the BMDM cells. |
| In vitro | 在RAW 264.7细胞中，Antitumor agent-19（10 µM、20 µM或50 µM）有效地且剂量依赖性地诱导M1型巨噬细胞标志物的表达，包括IL-1β、TNF-α、iNOS和IL-12α。Antitumor agent-19剂量依赖性地将肿瘤相关巨噬细胞从M1（抗肿瘤）再极化为M2（促肿瘤）[1]。 |
| In vivo | 在C57BL/6雌性小鼠携带Lewis肺癌细胞的模型中，Antitumor agent-19（5 mg/kg；i.p.）显著抑制了肿瘤生长。Antitumor agent-19与抗PD-1抗体联合使用，在体内展现了更为优越的抗肿瘤效果[1]。 |
| molecular weight | 487.9 |
| Molecular formula | C24H21ClF3N5O |
| CAS | 2379727-90-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 50 mg/mL (102.48 mM) |
| References | 1. Pei H, et al. iscovery of potent ureido tetrahydrocarbazole derivatives for cancer treatments through targeting tumor-associated macrophages. Eur J Med Chem. 2019 Sep 28;183:111741. |