| Description | Antifungal agent 59 exhibits potent activity, reflected by MIC values ranging from 0.01 to 1 μg/mL, and inhibits the formation of fungal biofilms, while maintaining safety [1]. |
| In vitro | 抗真菌剂59（化合物A23）在体外展现出显著的抗真菌活性，其最小抑菌浓度（MIC）分别为0.02 μg/mL和0.01 μg/mL针对白色念珠菌、0.25 μg/mL对玉米酵母念珠菌、0.25 μg/mL针对新型隐球菌、0.06 μg/mL对克氏念珠菌、1 μg/mL对光滑念珠菌、0.02 μg/mL针对近光滑念珠菌以及1 μg/mL对烟曲霉[1]。此外，抗真菌剂59在0.02 μg/mL浓度、48小时处理后能有效杀灭白色念珠菌[1]。该化合物在1-16 μg/mL浓度范围内对兔红细胞显示出溶血活性，且在8 μg/mL浓度时溶血率达到93.47%[1]。 |
| molecular weight | 456.19 |
| Molecular formula | C18H15BrF2N2Se |
| CAS | 2422019-96-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |