| Description | Antibacterial agent 105 (Compound 17) is a phenanthrolinic analog of quinolones. Antibacterial agent 105 exhibits antibacterial activity against M. tuberculosis with MIC 90 of 2.64 μM. Moreover, Antibacterial agent 105 exhibits antibacterial activities against different bacterial species with MIC 90 s of 11.18, 11.18，0.70，1.40，44.70, and 22.35 μM for M. smegmatis, M. aurum, M. marinum, BCG, E. aerogenes and S. aureus, respectively [1]. |
| In vitro | Antibacterial agent 105 (compound 17) has inhibitory effect on the growth of M. tuberculosis replicating in vitro cultured macrophages [1]. Antibacterial agent 105 (compound 17) (24 hours) has no toxicity on Vero cells line and human macrophages [1]. Antibacterial agent 105 (compound 17) has antibacterial activities against FQ resistant bacteria and XDR-TB [1]. |
| molecular weight | 299.24 |
| Molecular formula | C14H9N3O5 |
| CAS | 2364493-24-1 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |