| Description | Anti-virus agent 1 (compound 4i), a phosphoramidate prodrug of GS-5734, exhibits potent antiviral efficacy. It is primarily utilized in the study of coronavirus and Ebola virus (EBOV). |
| In vitro | Anti-virus agent 1 (compound 4i) has antiviral activity for EBOV in HeLa cell (EC 50 =1845 nM), HMVEC cell (TERT-immortalized human foreskin microvascular endothelial cells; ATCC-4025; EC 50 =367 nM), human macrophages (EC 50 =297 nM). Anti-virus agent 1 has a CC 50 of 21 μM in MT4 cell (human leukemia T-cell)[1]. |
| Synonyms | Anti-virus agent 1, Remdesivir isopropyl ester analog |
| molecular weight | 560.504 |
| Molecular formula | C24H29N6O8P |
| CAS | 1911578-83-0 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Dustin Siegel , et al. Discovery and Synthesis of a Phosphoramidate Prodrug of a Pyrrolo[2,1-f][triazin-4-amino] Adenine C-Nucleoside (GS-5734) for the Treatment of Ebola and Emerging Viruses. J Med Chem. 2017 Mar 9;60(5):1648-1661. 2. Michael O' Neil Hanrahan Clarke, et al.Methods for treating arenaviridae and coronaviridae virus infections. US20170071964A1. |