| Description | Anti-inflammatory agent 54 (compound 9c), a Coixol derivative, exhibits anti-inflammatory properties by inhibiting the NF-κB pathway and reducing the expression of pro-inflammatory cytokines such as iNOS, TNF-α, IL-6, and IL-1β. It effectively suppresses LPS-induced nitric oxide (NO) production in RAW264.7 macrophages with an IC50 of 2.4 μM and demonstrates in vivo efficacy in a mouse auricular edema model [1]. |
| molecular weight | 328.32 |
| Molecular formula | C17H16N2O5 |
| CAS | 2924156-46-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |