| Description | Flo8, an anti-inflammatory and antioxidant agent, effectively suppresses the release of reactive oxygen species (ROS) and nitric oxide (NO) while inhibiting neuronal apoptosis by modulating inflammatory and apoptotic signaling pathways, showcasing potential utility in Parkinson's Disease (PD) research [1]. |
| In vitro | Compound Flo8 (5 μM, 10 μM, 18小时) 对BV2细胞活力的影响不大，而在(5 μM, 18小时)浓度和时间下可显著抑制BV2细胞内ROS生成。此外，Compound Flo8还能减少炎症因子在BV2细胞中的表达，从而降低SH-SY5Y细胞凋亡水平。同时，该化合物在(5 μM, 10 μM, 18小时)用量下，能抑制LPS诱导的小胶质细胞M1型极化，并促进M2型极化，以及抑制BV2细胞中LPS刺激下ERK、p38和JNK的磷酸化。 |
| In vivo | 化合物Flo8（15/35 mg/kg，腹腔注射，每天/两周）对于MPTP诱导的C57BL/6J小鼠大脑神经炎症具有缓解作用，并能抑制神经元凋亡[1]。 |
| molecular weight | 394.42 |
| Molecular formula | C25H18N2O3 |
| CAS | 2925288-12-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |