| Description | Aniline mustard (Mesylerythrol) is alkylating mustard with anti-neoplastic activity. |
| Synonyms | Mesylerythrol, NSC-18429, N,N-双(2-氯乙基)苯胺, Lymphocin |
| molecular weight | 218.12 |
| Molecular formula | C10H13Cl2N |
| CAS | 553-27-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility | DMSO: 55 mg/ml (252.15 mM) |
| References | 1. Chen CH, Hu TH, Huang TC, Chen YL, Chen YR, Cheng CC, Chen CT. Delineation of G-Quadruplex Alkylation Sites Mediated by 3,6-Bis(1-methyl-4-vinylpyridinium iodide)carbazole-Aniline Mustard Conjugates. Chemistry. 2015 Nov 23;21(48):17379-90. doi: 10.1002/chem.201502595. Epub 2015 Oct 13. PubMed PMID: 26769627. 2. Fedeles BI, Zhu AY, Young KS, Hillier SM, Proffitt KD, Essigmann JM, Croy RG. Chemical genetics analysis of an aniline mustard anticancer agent reveals complex I of the electron transport chain as a target. J Biol Chem. 2011 Sep 30;286(39):33910-20. doi: 10.1074/jbc.M111.278390. Epub 2011 Aug 10. PubMed PMID: 21832047; PubMed Central PMCID: PMC3190774. 3. Benckhuysen C, Ter Hart HG, Van Dijk PJ. Enhanced cytostatic effectiveness of aniline mustard against 7,12-dimethylbenz[a]anthracene-induced rat mammary tumors during regression in response to ovariectomy. Cancer Treat Rep. 1981 Jul-Aug;65(7-8):567-74. PubMed PMID: 6788369. 4. McClean S, Costelloe C, Denny WA, Searcey M, Wakelin LP. Sequence selectivity, cross-linking efficiency and cytotoxicity of DNA-targeted 4-anilinoquinoline aniline mustards. Anticancer Drug Des. 1999 Jun;14(3):187-204. PubMed PMID: 10500495. |