| Description | AMPK activator C2 is an AMPK allosteric activator. |
| Synonyms | Compound 2, Compound-2, C2 |
| molecular weight | 231.1 |
| Molecular formula | C7H6NO6P |
| CAS | 1428422-55-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Langendorf CG, Ngoei KR, Scott JW, Ling NX, Issa SM, Gorman MA, Parker MW, Sakamoto K, Oakhill JS, Kemp BE. Structural basis of allosteric and synergistic activation of AMPK by furan-2-phosphonic derivative C2 binding. Nat Commun. 2016 Mar 8;7:10912. doi: 10.1038/ncomms10912. PubMed PMID: 26952388; PubMed Central PMCID: PMC4786773. 2. Ljubicic V, Jasmin BJ. Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle. Muscle Nerve. 2015 Jul;52(1):139-42. doi: 10.1002/mus.24692. Epub 2015 May 14. PubMed PMID: 25908446. 3. Hunter RW, Foretz M, Bultot L, Fullerton MD, Deak M, Ross FA, Hawley SA, Shpiro N, Viollet B, Barron D, Kemp BE, Steinberg GR, Hardie DG, Sakamoto K. Mechanism of action of compound-13: an α1-selective small molecule activator of AMPK. Chem Biol. 2014 Jul 17;21(7):866-79. doi: 10.1016/j.chembiol.2014.05.014. PubMed PMID: 25036776; PubMed Central PMCID: PMC4104029. 4. Li AJ, Wang Q, Ritter S. Participation of hindbrain AMP-activated protein kinase in glucoprivic feeding. Diabetes. 2011 Feb;60(2):436-42. doi: 10.2337/db10-0352. PubMed PMID: 21270255; PubMed Central PMCID: PMC3028342. |