| Description | Ampicillin Trihydrate (NCI-C56086), a broad-spectrum semisynthetic derivative of aminopenicillin, is a β-lactam antibiotic. |
| In vitro | 在绵羊和山羊中,Ampicillin Trihydrate (10 mg/kg)半衰期分别是2.48和1.2小时.在小鼠和大鼠中,Ampicillin Trihydrate (0.18 kg/kg-3 kg/kg) 不会造成腹泻或死亡. |
| In vivo | SP34中加入Ampicillin Trihydrate（500 mg）,能够产生有效的杀菌效果并抑制其生长。 |
| Synonyms | NCI-C56086, 氨苄青霉素三水合物 |
| molecular weight | 403.45 |
| Molecular formula | C16H19N3O4S·3H2O |
| CAS | 7177-48-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 4.03 mg/mL (10 mM), Sonication is recommended. |
| References | 1. Lacy MK, et al. Antimicrob Agents Chemother, 1999, 43(3), 672-677. 2. Elsheikh HA, et al. J Vet Pharmacol Ther, 1997, 20(4), 262-266. 3. Dunnick JK, et al. Toxicology, 1989, 56(2), 123-136. 4. Membrez M, et al. FASEB J, 2008, 22(7), 2416-2426. 5. Brown MP, et al. Equine Vet J, 1984, 16(4), 371-373. |
| Citations | 1. Li T, Lu D, Yao C, et al. Kansl1 haploinsufficiency impairs autophagosome-lysosome fusion and links autophagic dysfunction with Koolen-de Vries syndrome in mice. Nature Communications. 2022, 13(1): 1-16. |