| Description | Amphotericin B methyl ester is the derivative of the antibiotic Amphotericin B. Amphotericin B methyl ester is the cholesterol-binding compound that possesses significant antifungal activity. It disrupts HIV-1 particle production and potently inhibits HIV-1 replication. |
| In vitro | Amphotericin B methyl ester inhibits HIV-1 particle production with no significant effect on Gag binding to the plasma membrane, Gag association with lipid rafts, or Gag multimerization [1]. |
| molecular weight | 938.118 |
| Molecular formula | C48H75NO17 |
| CAS | 36148-89-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Waheed AA, et al. Inhibition of human immunodeficiency virus type 1 assembly and release by the cholesterol-binding compound amphotericin B methyl ester: evidence for Vpu dependence. J Virol. 2008 Oct;82(19):9776-81. 2. Keim GR, et al. Comparative toxicological studies of amphotericin B methyl ester and amphotericin B in mice, rats, and dogs. ntimicrob Agents Chemother. 1976 Oct;10(4):687-90. |