| Description | AMP-579 is an adenosine A1 receptor agonist. AMP-579 also acts as a A2b-adenosine receptor agonist in human 293 cells and rabbit hearts. |
| Synonyms | RPR100579, RPR 100579, AMP 579, RPR-100579 |
| molecular weight | 478.01 |
| Molecular formula | C22H28ClN5O3S |
| CAS | 143395-98-6 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Saegusa N, Sato T, Ogura T, Komuro I, Nakaya H. Inhibitory effects of AMP 579, a novel cardioprotective adenosine A1/A2A receptor agonist, on native IKr and cloned HERG current. Naunyn Schmiedebergs Arch Pharmacol. 2004 Dec;370(6):492-9. PubMed PMID: 15558241. 2. Kristo G, Yoshimura Y, Keith BJ, Stevens RM, Jahania SA, Mentzer RM Jr, Lasley RD. Adenosine A1/A2a receptor agonist AMP-579 induces acute and delayed preconditioning against in vivo myocardial stunning. Am J Physiol Heart Circ Physiol. 2004 Dec;287(6):H2746-53. PubMed PMID: 15271662. 3. Xu Z, Downey JM, Cohen MV. Timing and duration of administration are crucial for antiinfarct effect of AMP 579 infused at reperfusion in rabbit heart. Heart Dis. 2003 Nov-Dec;5(6):368-71. PubMed PMID: 14633317. 4. Xu Z, Jiao Z, Cohen MV, Downey JM. Protection from AMP 579 can be added to that from either cariporide or ischemic preconditioning in ischemic rabbit heart. J Cardiovasc Pharmacol. 2002 Oct;40(4):510-8. PubMed PMID: 12352312. |