| Description | Ammonium formate (Formic acid ammonium salt) is the simplest carboxylic acid. Formate is an intermediate in normal metabolism. It is responsible for both metabolic acidosis and disrupting mitochondrial electron transport and energy production by inhibiting cytochrome oxidase activity, the terminal electron acceptor of the electron transport chain. Cell death from cytochrome oxidase inhibition by formate is believed to result partly from depletion of ATP, reducing energy concentrations so that essential cell functions cannot be maintained. Furthermore, inhibition of cytochrome oxidase by formate may also cause cell death by increased production of cytotoxic reactive oxygen species (ROS) secondary to the blockade of the electron transport chain. |
| Synonyms | 甲酸铵, Formic acid ammonium salt |
| molecular weight | 63.06 |
| Molecular formula | CH5NO2 |
| CAS | 540-69-2 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| Solubility | DMSO: 60 mg/mL (951.47 mM) |
| References | 1. Hodson BA, et al. Novel affinity chromatographic system for the single-step purification of glycosaminoglycans from complex systems using volatile buffers. J Chromatogr. 1991 Apr 19;565(1-2):416-23. |
| Citations | 1. He L, Shen L, Zhang J, et al.Comprehensive Investigation of Fluoroquinolone Residues in Apis mellifera and Apis cerana Honey and Potential Risks to Consumers: A Five-Year Study (2014–2018) in Zhejiang Province, China.Toxics.2023, 11(9): 744. |