| Description | Amisulpride is an antagonist of 5-HT7 receptor and dopamine D2 and D3 receptors. It modulates beta 2- arresting signaling and increases neurite outgrowth. |
| Target activity | D3 receptor:3.2 nM (Ki), D2 receptor:2.8 nM (Ki) |
| Synonyms | APD-421, Amisulpride HCl, APD 421, APD421, Sultopride, 氨磺必利盐酸盐 |
| molecular weight | 405.94 |
| Molecular formula | C17H28ClN3O4S |
| CAS | 81342-13-4 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Jang YJ, Jeong TC, Noh K, Baek IW, Kwon KI, Kim E, Yoon YR, Kang W. Prandial effect on the systemic exposure of amisulpride. Arch Pharm Res. 2014 Oct;37(10):1325-8. doi: 10.1007/s12272-014-0331-7. Epub 2014 Jan 29. PubMed PMID: 24469600. 2. Huang LC, Huang LY, Tseng SY, Hou YM, Hsiao CC. Amisulpride and symptomatic bradycardia: a case report. Gen Hosp Psychiatry. 2015 Sep-Oct;37(5):497.e1-2. doi: 10.1016/j.genhosppsych.2013.12.005. Epub 2013 Dec 16. PubMed PMID: 26162544. 3. Donahue TJ, Hillhouse TM, Webster KA, Young R, De Oliveira EO, Porter JH. (S)-amisulpride as a discriminative stimulus in C57BL/6 mice and its comparison to the stimulus effects of typical and atypical antipsychotics. Eur J Pharmacol. 2014 Jul 5;734:15-22. doi: 10.1016/j.ejphar.2014.03.047. Epub 2014 Apr 12. PubMed PMID: 24726559. 4. Loy F, Isola M, Isola R, Lilliu MA, Solinas P, Conti G, Godoy T, Riva A, Ekström J. The antipsychotic amisulpride: ultrastructural evidence of its secretory activity in salivary glands. Oral Dis. 2014 Nov;20(8):796-802. doi: 10.1111/odi.12209. Epub 2013 Dec 10. PubMed PMID: 24245711. |