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Amino-PEG4-(CH2)3CO2H

CAS No.: 144598-03-8

Amino-PEG4-(CH2)3CO2H is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC mo
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Description Amino-PEG4-(CH2)3CO2H is a PEG-based linker for PROTACs which joins two essential ligands, crucial for forming PROTAC molecules. This linker enables selective protein degradation by leveraging the ubiquitin-proteasome system within cells.
In vitro PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins[1].
molecular weight 279.33
Molecular formula C12H25NO6
CAS 144598-03-8
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. An S, et al. Small-molecule PROTACs: An emerging and promising approach for the development of targeted therapy drugs. EBioMedicine. 2018 Oct;36:553-562