PeptideDB

AMG8163

CAS No.: 659731-59-6

AMG8163 is an antagonist of vanilloid receptor TRPV1.
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Description AMG8163 is an antagonist of vanilloid receptor TRPV1.
Synonyms AMG 8163, AMG-8163
molecular weight 545.53
Molecular formula C25H22F3N5O4S
CAS 659731-59-6
Storage Powder: -20°C for 3 years | In solvent: -80°C for 1 year
References 1. Gavva NR, Bannon AW, Hovland DN Jr, Lehto SG, Klionsky L, Surapaneni S, Immke DC, Henley C, Arik L, Bak A, Davis J, Ernst N, Hever G, Kuang R, Shi L, Tamir R, Wang J, Wang W, Zajic G, Zhu D, Norman MH, Louis JC, Magal E, Treanor JJ. Repeated administration of vanilloid receptor TRPV1 antagonists attenuates hyperthermia elicited by TRPV1 blockade. J Pharmacol Exp Ther. 2007 Oct;323(1):128-37. Epub 2007 Jul 25. PubMed PMID: 17652633. 2. Gavva NR, Bannon AW, Surapaneni S, Hovland DN Jr, Lehto SG, Gore A, Juan T, Deng H, Han B, Klionsky L, Kuang R, Le A, Tamir R, Wang J, Youngblood B, Zhu D, Norman MH, Magal E, Treanor JJ, Louis JC. The vanilloid receptor TRPV1 is tonically activated in vivo and involved in body temperature regulation. J Neurosci. 2007 Mar 28;27(13):3366-74. PubMed PMID: 17392452.