| Description | AMG-222 (ALS-2-0426, ALS-20426) is a DPP-4 inhibitor and may be used in the treatment of type 2 diabetes. |
| Synonyms | AMG 222, ALS-2-0426 free base, ALS-2-0426, ALS-20426 |
| molecular weight | 597.71 |
| Molecular formula | C32H39N9O3 |
| CAS | 913978-37-7 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year |
| References | 1. Kiang YH, Cheung E, Stephens PW, Nagapudi K. Structural studies of a non-stoichiometric channel hydrate using high resolution X-ray powder diffraction, solid-state nuclear magnetic resonance, and moisture sorption methods. J Pharm Sci. 2014 Sep;103(9):2809-18. doi: 10.1002/jps.23873. Epub 2014 Jan 27. PubMed PMID: 24470123. 2. Kiang YH, Nagapudi K, Liu J, Staples RJ, Jona J. Crystal structure study and investigation of solid-state cyclization for AMG 222, a channel hydrate. Int J Pharm. 2013 Jan 30;441(1-2):299-306. doi: 10.1016/j.ijpharm.2012.11.029. Epub 2012 Nov 23. PubMed PMID: 23182974. 3. Greene RJ, Tu H, Gibbs JP, Greg Slatter J. Target-mediated metabolism and target-mediated drug disposition of the DPPIV inhibitor AMG 222. Xenobiotica. 2011 Nov;41(11):945-57. doi: 10.3109/00498254.2011.597455. Epub 2011 Aug 25. PubMed PMID: 21867423. |